Same Names Different Faces
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Rachel Dawes
Batman's love interest switched actresses from Katie Holmes to Maggie Gyllenhaal in The Dark Knight. Sorry, Bruce Wayne, but that's not an upgrade.
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Jim Rhodes (aka War Machine)
The calm Don Cheadle replaced the crazy-eyed and sweating Terence Howard in the Iron Man series and subsequent MCU films. That's like switching from Red Bull to decaf.
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Bruce Banner - The Hulk
Marvel finally found their (green) man with Mark Ruffalo, who looked better in ripped purple shorts than Eric Bana and Edward Norton.
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Lisbeth Salander
Claire Foy wore the infamous back tat, taking over the Lisbeth Salander role from Rooney Mara in the Girl With the Dragon Tattoo sequel.
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Red Skull
Genius impressionist/actor Ross Marquand (of The Walking Dead) put on the prosthetics to revive Captain America's nemesis in Infinity War. The face-melted Nazi was originally played by Hugo Weaving.
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Victoria
Bryce Dallas Howard swooped into the villainous Twilight role in place of Rachelle Lefevre for the third film. Talk about ginger-on-ginger crime.
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Albus Dumbledore
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V
It's rare to get the heave-ho during the shooting of a film, but that's exactly what happened to James Purefoy for V for Vendetta. His replacement? None other than Hugo Weaving.